By Franz Joel Leong, Veronique Dartois, Thomas Dick
An annual dying toll of two million, coupled with emerging drug resistance, highlights the necessity for the advance of recent medicines, higher diagnostics, and a tuberculosis (TB) vaccine. Addressing those key matters, a colour Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, scholars, scientists, and medical professionals operating, studying, and educating within the box of TB. It comprises a hundred colour photos and illustrations that convey readability to the knowledge offered. The atlas takes the bizarre procedure of protecting a number of species histopathology, arguably the 1st and relatively most likely the one source to take action. It presents an easy, annotated, and visible presentation of the comparative histopathology of TB in human and animal types. The editors have compiled info that is helping TB scientists to differentiate among the good points of all significant animal versions to be had and to take advantage of them with their strengths and boundaries in brain. The e-book offers counsel for choosing the simplest animal model(s) to reply to particular questions and to check the efficacy of drug applicants.
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Additional info for A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis
B. 1962. Host–parasite relationships in natively resistant and susceptible rabbits on quantitative inhalation of tubercle bacilli. Their significance for the nature of genetic resistance. Am Rev Respir Dis, 85, 553–569. , and Young, D. 2009. The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies. Nat Rev Microbiol, 7, 845–855. J. 2008. Experimental tuberculosis: The role of comparative pathology in the discovery of improved tuberculosis treatment strategies. Tuberculosis (Edinb), 88 Suppl 1, S35–47.
Goblet Cells Goblet cells are the most common nonciliated cell and are present in all bronchi but not in the bronchioles. 5). The goblet cell is characterized by abundant apical collections of mucus granules that form the “goblet” appearance. These granules are released into the bronchial lumen by fusion and fenestration of the membranes of both granules and cell, in the manner of merocrine-type secretions. Secretion of mucus in the lung, as in the intestines, is thought to serve a protective function, but excess secretion may obliterate the air passage, especially in small scarred airways.
Nude rat (F344/N-rnu) tuberculosis. Cell Microbiol, 8, 661–667. M. 2003. Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis. Infect Immun, 71, 864–871. , 3rd. 2008. Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect Immun, 76, 2333–2340. J. 2009. Eliminating latent tuberculosis. Trends Microbiol, 17, 183–188. II 29 Chapter 4 Anatomy and Histology of the Human Lung F. -M. -Y. , 1984; Kayser, 1992; Hasleton and Curry, 1996; Colby and Yousem, 1997), and this chapter 31 32 â•›â†œ◾â†œæ¸€ A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis serves as a review of the basic features necessary to understand the functional and pathological changes that can occur in this organ.