Acquired Neuromuscular Disorders: Pathogenesis, Diagnosis by Corrado Angelini

By Corrado Angelini

This booklet presents cutting-edge details at the pathogenesis, analysis, and remedy of a variety of inflammatory, autoimmune, and idiopathic neuromuscular issues. the hole part discusses the differential prognosis of obtained myopathies in keeping with medical, electrophysiological, muscle biopsy, and serological standards, with designated specialize in the function of electromyography and antibody trying out. all of the appropriate scientific entities is then mentioned intimately, the insurance together with, for instance, myasthenia gravis, polymyositis, immune-mediated neuropathies, multifocal motor neuropathies, amyotrophic lateral sclerosis, paraneoplastic neuropathies, and diabetic polyneuropathy. transparent information is equipped on at present to be had remedies, with descriptions of the newest advances in physiotherapy, drug remedy, and respiration care. different good points of this clinically orientated booklet are the inclusion of many illustrative case displays and contributions through overseas authors from best centers.

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Extra resources for Acquired Neuromuscular Disorders: Pathogenesis, Diagnosis and Treatment

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Clin Neurophysiol 122:1873–1877 34. Querol L, Illa I (2013) Myasthenia gravis and the neuromuscular junction. Curr Opin Neurol 26:459–465 35. Engel AG, Shen XM, Selcen D, Sine SM (2015) Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment. Lancet Neurol 14:420–434 36. Evoli A, Liguori R, Romani A, Mantegazza R, Di Muzio A, Giometto B, Pegoraro E, Rodolico C, Vigliani MC, Italian Working Group on Myasthenic Syndromes (2014) Italian recommendations for Lambert-Eaton myasthenic syndrome (LEMS) management.

The CRD have been described both in muscle and peripheral nerve diseases. Since CRD are very frequent in adult onset form of Pompe disease and especially in paraspinal muscles, they have been included as a diagnostic feature in the diagnostic guidelines of the American Association of Neuromuscular and Electrodiagnostic Medicine [19]. CRD are rarely observed in LGMD and FSHD, while they seem to be more frequent in Duchenne than in Becker muscular dystrophies [20]. CRD are also present in almost half of patients affected by sIBM, with a higher frequency in paravertebral muscles.

36 L. Santoro and F. Manganelli References 1. Sherrington CS (1929) Some functional problems attaching to convergence. Proc Roy Soc B 105:332 2. Bourke RE (1981) Motor units: anatomy, physiology, and functional organization. In: Brooks VB (ed) Handbook of physiology, vol 2, The nervous system Vol. 2. Motor control. American Physiological Society, Bethesda, pp 2345–2412 3. Henneman E, Mendel LM (1981) Functional organization of motor neuron pool and its inputs. In: Brooks VB (ed) Handbook of physiology, The nervous system.

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