An Introduction to Medicinal Chemistry (5th Edition) by Graham L. Patrick

By Graham L. Patrick

An creation to Medicinal Chemistry is the major textual content for collage classes in this topic. popular for being a textbook enjoyed both by means of either scholars and academics, it offers entire insurance in an obtainable and fascinating sort.

The textual content starts with the basic biochemistry on which an knowing of medicinal chemistry is equipped, introducing the constitution and serve as of significant drug ambitions. It then explores how medicinal drugs have interaction with the physique and the implications of these reactions. there's a part on normal ideas and techniques taken with studying and designing new medicinal drugs, and one other on invaluable 'tools of the trade'. The textual content ends with a modern examine particular themes inside of medicinal chemistry, for instance, antiviral and anticancer brokers; cholinergics and anticholinesterases; and antiulcer agents.

Learning positive factors all through An advent to Medicinal Chemistry support to free up this attention-grabbing topic. A thesaurus is helping to familiarise the language of medicinal chemistry. containers current in-depth fabric and discover how ideas are utilized in perform. Key issues summarise sections inside of chapters, supplying a foundation for revision, and questions on the finish of chapters and at the accompanying on-line source Centre let the reader to check their realizing and boost molecular modelling skills.

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Additional info for An Introduction to Medicinal Chemistry (5th Edition)

Sample text

6 Role of the planar peptide bond Planar peptide bonds indirectly play an important role in tertiary structure. Bond rotation in peptide bonds is hindered, with the trans conformation generally favoured, so the number of possible conformations that a protein can adopt is significantly restricted, making it more likely that a specific conformation is adopted. Polymers without peptide bonds do not fold into a specific conformation, because the entropy change required to form a highly ordered structure is extremely unfavourable.

1 and Case study 5). It is not possible for water to solvate the non-polar or hydrophobic regions of a drug or its target binding site. Instead, the surrounding water molecules form strongerthan-usual interactions with each other, resulting in a more ordered layer of water next to the non-polar surface. This represents a negative entropy due to the increase in order. When the hydrophobic region of a drug interacts with a hydrophobic region of a binding site, these water molecules are freed and become less ordered (Fig.

Pharmacodynamics is the study of how drugs interact with their targets and produce a pharmacological effect. • Electrostatic or ionic interactions occur between groups of opposite charge. • Hydrogen bonds occur between an electron-rich heteroatom and an electron-deficient hydrogen. • The functional group providing the hydrogen for a hydrogen bond is called the hydrogen bond donor. The functional group that interacts with the hydrogen in a hydrogen bond is called the hydrogen bond acceptor. • Van der Waals interactions take place between non-polar regions of molecules and are caused by transient dipole– dipole interactions.

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